Clinical Trials 
Currently Enrolling Studies:
| Study | # of Pts | Evaluating |
| OM8 | 0 | A study of a drug for Afib |
| MBG312 | 10 | A study of 123mibg in subjects with CHF |
| MADIT CRT | 6 | A study of ICD vs BiV ICD to decrease mortality in HF |
| CAPTURE 2 | 9 | A registry of carotid stents |
| ATI 2042 | 1 | A study of new drug for Afib |
| SPIRIT IV | 14/ 48 SF | A study of new DES |
| FREEDOM | 4 | A study of AV OP echo vs Quick Op |
| ARISTOTLE | 11 | A study of a new drug vs warfarin in Afib |
| ASCEND HF | 1 | A study of a Natecor vs placebo in ADHF |
| PLATO | 0 | A study of a new drug vs clopidogrel in ACS |
| CLEAR | 1 | A study of a pacemaker rate changes |
| VASCULAR WRAP | 13 | A study of new wrap for hemodialysis grafts |
Closed to Enrollment but still following:
| Study | # of Pts | Evaluating |
| TRUST | 26 | A study of home monitoring of ICDs |
| PAS | 47 | A post approval study of BiV ICDs |
| COSTAR II | 3 | A study of a drug eluting stent |
| ARRIVE 2 | 45 | A registry of Taxus DES |
| DeCode | 8 | A study of home monitoring of BP, Weight & BiV ICD |
| INSYNC Registry | 38 | A post market study of InSync pacemaker patients |
| Triage | 13 | A study of home monitoring of BP, Weight & BiV ICD |
| Champion Platform | 9 | A study of cangrelar vs usual care in PCI |
| Champion PCI | 3 | A study of cangrelar vs clopidogrel in PCI |
| ACT | 26 |
A registry of ICD implants |
Completed Trials:
| Study Name | # of Pts | Evaluated |
| Subpectoral Implantation of ICD | 8 | A study to determine the safety and efficacy of a nonepicardial ICD using transvenous lead & submuscular patch in patients with life threatening arrthythmias |
| MUSTT | 32 | Multicenter Unsustained Tachycardia Trial |
| IV Amiodarone | 5 | An open label safety study of Intravenous Amiodarone HCI in pts with life threatening ventricular tachycardia/fibrillation |
| VIGOR SR | 5 | A study of the safety and efficacy of the CPI single chamber VIGOR SR pulse generator, models 1130 & 1135 & the associated software module Model 2075 |
| Models 7217B & 7219E PCDs with Endotak 60 | 22 | A study of the safety and effectiveness of ENDOTAK 60 series lead system (JEWEL) in detecting & treating VT & VF |
| Ventak Prx III HC AICD | 3 | A study of the safety & efficacy of a Ventak PRx with the pulse gererator can being an active electrode (hot can) vs non-active can (cold can) |
| Trilogy DR+ Models 2360L & 2364L | 18 | A study to evaluate the operation, safety & efficacy of the Trilogy DR+ pulse generator in pts requiring dual chamber, rate responsive pacemakers for bradycardia |
| Model 1242T & 1246T Endocardial Pacing Leads | 1 | A study of Pacesetter passive plus bipolar, endocardial pacing leads |
| Model 7218 ICD | 10 | A study of the safety & effectiveness of Medtronic Model SPI system used in the detection & treatment of VT & VF |
| CPI Pace/Sense Acute Study Device (PS-ASD) | 7 | A study of the pacing & sensing capabilities of PS-ASD devices |
| Trilogy SR+ Models 2260L & 2264L | 3 | A study to evaluate the operation, safety and efficacy of the Trilogy SR+ pulse generator in pts requiring an implanted, single chamber, rate responsive pacemaker for bradycardia |
| Tendril DX Endocardial lead | 56 | A study of the safety & efficacy of the Tendril DX model 1388T steriod eluting screw in pacing lead |
| PURSUIT | 46 | A randomized, double blind evaluation of the efficacy & safety of 2 dosing regimens of Integrelin vs placebo for reducing mortality & MI in pts with unstable angina or Non Q wave MI |
| Aegis Model 2600 | 1 | A study of the safety and efficacy of the Aegis Model 2600 |
| OPUS 1 | 28 | A randomized, controlled trial to compare clinical restenois rates, quality of life & costs in pts treated with "optimal" PTCA with stent only when necessary vs routine stent use |
| Prophylaxis w/Sotalol | 60 | A study to evaluate the efficacy of sotalol in preventing post operative Afib/Aflutter in the cardiac surgery patient. It also accessed the SAECG as a predictor. |
| Aplaud | 7 | A double blind placebo controlled study to access safety, tolerability, pharmacokinetics & effect on platelet aggrefation of a dose range of SB 214857 with aspirin in pts with MI, unstable angina, TIA or stroke |
| REOMI | 6 | A study of the effect of Glycoprotien 11b/111a inhibition without thrombolytic therapy on reperfusion in acute MI |
| High Frequency Stimulation | 1 | To determine if high frequency stimulation induced cardioversion is possible by prolonging the afib cycle lengths in pts w/persistent afib treated w/propfanone. |
| Retavase | 2 | A study of prehospital use of the thrombolytic Retavase |
| Symphony | 8 | A phase III randomized double blind, aspirin controlled trial to evaluate the efficacy & safety of sibrafiban, an oral platelet glycoprotein 11b/111a antagonist, as therapy for the prevention of secondary vascular events in pts after acute coronary syndrome |
| Acute | 4 | A randomized trial to investigate a TEE guided approach to anti coagulation management to decrease incidence of embolization after cardioversion |
| Internal Cardioversion | 5 | A study of intracardiac defibrillation in pts with afib who failed conventional transthoracic cardioversion. |
| Trumpet | 5 | A phase IV study of the lipid changes in patients treated with Tricor |
| Cook Balloon | 13 | A study of the new MBC balloon dilatation catheters. |
| BH88 | 59 | To test the Ensure diagnostic concept for predicting an individual's cholesterol responsiveness to diet therapy. |
| Prince | 2 | A study of the effect of pravastatin on plasma levels of C reactive protein (hs-CRP) in primary and secondary prevention. |
| Corinthian | 1 | To evaluate the safety and effectiveness of the Cordis Palmaz Corinthian stent in iliac patients after suboptimal PTA. |
| EGM Width | 12 | A evaluation of changes in EGM width over time and with changes in body position. |
| 6944 ICD Lead | 28 | A phase I study of new Medtronic ICD lead. |
| Copernicus | 4 | A trial to determine the effect of carvedilol on mortality in patients with severe chronic heart failure. |
| Ultra Revive | 14 | A study of the ACS Multi Link Ultra coronary stent in pts with saphenous graft & de novo native lesions. |
| Revive | 10 | A non randomized evaluation of the ACS Multi link duet coronary stent system in saphenous vein grafts |
| Microny/Regency | 17 | To evaluate the safety and efficacy of the Microny SR+ & Regency SR+ pacemakers when used in combination with Tendril DX or passive plus DX leads |
| Cadillac | 44 | To compare clinical outcomes between the ACS RX Multilink stent to ptca when used within 12 hours of acute MI. |
| Suport | 16 | A study to compare Scimed NIR stent vs ACS Multilink Duet. |
| Octave | 3 | A comparison of omapatrilat vs enalapril for hypertension |
| Bravo | 3 | A study to compare the incidence of clinical events in pts receiving lotrafiban or placebo combined w/aspirin. |
| DTI-0009 | 17 | Outpatient intravenous drug fo treatment of narrow QRS complex tachycardia or atrial fibrillation/flutter |
| Replace | 5 | A study of angiomax in percutaneous coronary intervention to reduce clinical events. |
| MIST | 1 | A comparison of two stents in de novo or restenotic iliac arteries with suboptimal PTA. |
| ICD Septal Lead | 1 | A study to show if defibrillation thresholds can be reduced by placing the RV coil along the interventricular septum |
| Open Label Carvedilol | 1 | A open label study of Carvedilol in patients that participated in the Copernicus study. |
| Adopt A | 39 | A randomized trial to evaluate new pacemaker algorithm for over-drive pacing for prevention of Afib. |
| OriginEP | 9 | A study to assess the practical feasibility of the noninvasive OriginEP multi-electrode ECG mapping system in recording single beats. |
| RVA vs RVOT | 3 | A comparison of exercise capacity in patients with pacing leads in the right ventricular apex vs the right ventricular outflow tract. |
| WCD | 1 | Study of the safety and effectiveness of the Wearable Cardioverter Device in transplant, complicated post MI and complicated coronary bypass patients. |
| ASSURE | 1 | To diagnosis recurrent, unexplained syncope using the Reveal Plus ILR compared with conventional strategies |
| Aspire2 | 12 | To evaluate the safety and efficacy of renal artery stenting compared to balloon angioplasty alone. |
| TP 10 | 35 | A phase II study to address the negative effects of complement activation during and following coronary artery bypass surgery |
| Astaxanthin | 101 | Astaxanthin supplementation and potential reduction of C-reactive protein levels. |
| A Comet 1/A Star | 2 | To assess efficacy of daily oral azim2HCl vs placebo in treating or preventing Afib |
| DTI0009 Phase 2 | 2 | A randomized, dose response trial of IV DTI-0009 for ventricular rate control in adult patients with Afib |
| CRAFT | 6 | A trial of the tolerance & efficacy of RSD1235 in patients with recent onset Afib |
| Amiovirt | 4 | A randomized trial for patients with NSVT and non ischemic myopathy randomized to amiodarone or ICD. |
| Credo | 7 | A double-blind randomized trial of clopidogrel & aspirin for the prevention of vascular events and mortality in pts undergoing coronary intervention. |
| RID-AF | 45 | A study to show reduced incidence & duration of AF/AT with the Jewel AF Dual Chamber AMD. |
| TOVA | 11 | Study of ICD patients to gain insight into triggering of potentially lethal arrthymias. |
| Amiodarone Aqueous I.V. | 19 | A comparison of the incidence of hypotension with 2 formulations of IV amiodarone: Cordarone IV vs Aqueous Amiodarone IV injection. |
| COMMA | 3 | A trial of two IV dosing regimens of h5G1.1-scFv in pts with acute MI undergoing PTCA |
| IMPACT | 4 | A study of the impact of medical speciality on patiant compliance to treatment |
| MedHall Outcomes | 9 | Influence of prosthetic valve type and orientation on clinical and hemodynamic outcome after aortic valve replacement. |
| CRUSADE | 49 | A QI study of risk stratification of unstable angina to suppress adverse outcomes with early implementation of ACC/AHA guidelines |
| Vascucoil | 27 | To clinical investigation of the Vascucoil self expanding peripheral stent. |
| Valiant | 24 | A comparison of efficacy & safety of long term treatment with valsartan, catopril & their combination in high risk patients after MI. |
| Soar | 6 | A non randomized, prospective, multi-center, consecutive registry of sub-optimal renal angioplasty. |
| Navi Star Thermo Cool | 6 | Evaluation of the Navi Star Thermo Cool Catheter w/Stockert 70 radiofrequency generator for endocardial ablation in pts w/a flutter |
| Charm | 3 | Candesartan in Heart Failure-Assessment of reduction in mortality and morbidity. |
| Natural History of Afib | 25 | A prospective, randomized, parallel group, single blinded study of pts w/Afib, no cardioversion and a need for a dual chamber pacemaker. |
| REPLACE2 | 31 | A study of angiomax in percutaneous coronary intervention to reduce clinical events |
| PRIMO CABG | 18 | A trial of pexelizumab on total mortality & Mi in pts undergoing CABG |
| Pride | 308 | Effects of Heart Disease Education on Older Women |
| SCDHeFT/T Wave Alternans | 79/28 | A randomized study of effectiveness of Amiodarone (or placebo) vs. defibrillator in reducing SCD in HF. |
| PROVE-IT | 4 | A double-blind, randomized trial for patients who have experienced an acute coronary syndrome to compare two statin drugs and examine the role of infection. |
| ABCD | 1 | A prospective multi center study to determine the effectiveness of TWA in predicting VT events in pts with ischemic disease and NSVT. |
| Stamina HFP | 25 | A study of Anemia in a Heart Failure Population |
| Definite | 7 | Defibrillators in non-ischemic cardiomyopathy treatment evaluation. |
| JUMBO | 5 | A study to evaluate a new oral antiplatelet agent in PCI with Stent |
| ENPULSE | 3 | A study to evaluate a new pacemaker feature |
| Sudden Death Athletic Screen | 457 | Can a hospital based screening program identify athletes at rick for sudden cardiac death |
| SYNERGY | 18 | A trial to compare low molecular weight heparin, enoxaparin vs unfractionated heparin in high risk patients with non ST elevation acute coronary syndromes |
| ITI Iliac Stent | 17 | A randomized trial of Intratherapeutic's iliac stent for iliac artery occlusion/Suboptimal angioplasty. |
| ESSENTIAL | 4 | A trial of oral Enoximone vs placebo in advanced chronic heart failure subjects |
| PREVENT IV | 31 | A study to compare CGT003 (an E2F decoy) to placebo in pts undergoing CABG to inhibit neointima formation to prevent accelerated aterhosclerosis in vein grafts. |
| RESTORE | 10 | To demonstrate the ITI renal stent is safe & effective for treating renovascular htn caused by renal artery stenosis or occlusion |
| PROTEGE | 3 | A trial of the protege self expanding nitinol stent in iliac artery disease |
| RHYTHM | 42 | A trial of resynchronization for hemodynamic treatment for Heart Failure Management |
| SAFARI | 26 | A trial to evaluate the safety & efficacy of the Selection Model 9000 application in pts who are currently indicated for a dual chamber pacemaker |
| VIBRANT | 68 | A registry for value of information based from pacemaker recordings & new technology |
| VALOR | 3 | A study to evaluate contrast in coronary angiograms and interventions |
| TP10-002 | 6 | A study to of TP10 in women undergoing CABG |
| SPIDER | 9 | A study to evaluate a new distal protection device in PCI in SVG |
| ACT I | 25 | A study to evaluate a new drug for atrial fib and atrial flutter |
| DIARY | 3 | A study of CHF events in patients with BI V ICDs |
| PREVENT V | 3 | A study of E2F Decoy in hemodialysis grafts |
| PRIMO CABG II | 6 | A study of investigational drug vs placebo for patients undergoing CABG |
| ACT III | 6 | A study to evaluate a new drug for atrial fib and atrial flutter |
| ACT II | 2 | A study to evaluate a new drug for atrial fib and atrial flutter p cabg and or valve |
| STELLAR | 15 | A registry of the Cypher stent |
| FUSION II | 2 | A study comparing serial Natecor infusions to placebo in Class III & IV CHF |
| NAPA | 1 | A study of Natecor in CABG |
| ASSESS HF | 11 | A study of physican assessment of ICD home monitoring data |
| AWARE | 2 | A study of a new pacemaker AT/AF Detection Algorithm |
| GAMMA | 3 | A study to evaluate a new drug for ventricular tachycardia |
| AF CHF | 2 | To compare therapeutic strategy to restore and maintain sinus rhythm in patients with CHF and AF vs a strategy of rate control alone |
| OPTION | 11 | A study of the Tuplos Biotronik BI V ICD |
| HAT | 19 | A trial of home AEDs vs CPR |
| VICTORY | 17 | A study of a new pacemaker |
| PROVE | 48 | A study of ICD programming for VT |
| PAIRED | 8 | A study of home monitoring of a pacemaker |
| LINK | 10 | A study of a new ICD lead |
| APL Poly | 18 | A study of a new pacemaker lead |
| ACUITY | 19 | A study of Angiomax vs heparin in ACS |
| FSR | 5 | A study of a new pacemaker lead |
| RED HF | 4 SF | A study of a drug for anemia in CHF |
| EZ PATH | 3 | A study of exetimibe & statin in high risk patients |
| Protocol 24 | 1 | A study of naicin & statin |
| NAPA 3 | 1 | A study of a drug for acute peripheral artery occlusion |
| ACT IV | 11 | A study of a new drug for Afib |
| RETHINQ | 10 | A study of narrow QRS in CRT Therapy |
| RESTORE IT | 5, 23 SF | A study of an antibotic for carotid stenosis |
| Response HF | 11 | A study of CRT Therapy w/V-V timing for BiV ICDs |
| Epic II PAS | 3 | A study of patient notifier feature of ICD |
| Early ACS | 11 | A study of eptifibatide in non ST elevation ACS |
| AVE S7 Stent Registry | 6 | A post market study of Medtronic AVE S7 with discrete technology coronary stent |